Optimal Control in Design of Magnetic Resonance Experiments, PhD, at Faculty of Science, Charles University

Optimal Control in Design of Magnetic Resonance Experiments, PhD, Faculty of Science, Charles University

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The award	How you will study	Study duration	Course start	Domestic course fees	International course fees
PhD	Full-time	find out	find out	0	0

About Optimal Control in Design of Magnetic Resonance Experiments, PhD - at Faculty of Science, Charles University

Project summary

Together with our international partners, we develop numerical tools based on optimal control theory to design experimental techniques with improved performance for magnetic resonance. We focus on applications to solid-state nuclear magnetic resonance (NMR) of biomolecules such as proteins and amyloids. We work to exploit the emerging expertise and technology of ultrafast magic-angle-spinning (MAS) solid-state NMR spectroscopy at high magnetic fields and to streamline its application for daily structural biology routines in academic and industrial settings.

Optimal control allows one to develop completely new magnetization transfer experiments and strategies that are not achievable by any known pulse sequences. An example is heteronuclear transverse magnetization transfer that yields a sensitivity enhancement factor of 1.4 for every indirectly sampled dimension of multidimensional spectra. [1] This possibility of capturing both components of complex data (real and imaginary components) at the same time has revolutionized the prospects of high-dimensional solid-state NMR, shortening the experimental time of a 5D from months to a couple of days. Such high-dimensional spectra are essential for resolving spectral overlap and for obtaining unambiguous assignments of complex protein systems.

This PhD project will concentrate on further development of numerical methods and their implementation in the SIMPSON software package. [2] New pulse sequences for tailored magnetization transfers for ultrafast MAS proton detected high-dimensional spectroscopy will be developed. The project will be conducted in close collaboration with the Technical University of Munich (bio-solid-state NMR) and Aarhus University (SIMPSON), which are both equipped with the latest instrumentation necessary for experimental verification.

The ideal candidate should have programming and mathematical skills and basic knowledge of solid-state NMR.

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Entry requirements

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Fees, Funding and Scholarships at Faculty of Science, Charles University

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Students may obtain the following scholarships:

accommodation bursary;
bursary for a student in difficult social circumstances;
scholarship for outstanding academic achievement (“mark-based”);
bursary in a case worthy of special consideration;
bursary to support study abroad;
bursary for a CU student in an acutely difficult situation;
bursary to support study in the Czech Republic;
bursary for excellent research, development, innovation, artistic, or other creative achievements contributing to enhanced knowledge;
scholarship for RDI (research, development, and innovation) under special legislation;
motivation bursary for 1st year bachelor’s programme students;
motivation bursary for 1st year post-bachelor’s programme students;
sports bursary;
doctoral bursary.

Certain scholarships are granted to students automatically (without student applications), whereas others are granted further to an application (electronic or paper, depending on the type of scholarship). Bursaries are neither taxed nor included in stated income. You can find answers to frequently asked questions regarding scholarships on the Faculty website (natur.cuni.cz/fakulta/studium/helpdesk/faq-stipendia; Czech only).

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