Amphiphilic Peptidomimetics Containing Metallacarboranes as a Design Strategy for Future Antibiotics, PhD, at Faculty of Science, Charles University

Amphiphilic Peptidomimetics Containing Metallacarboranes as a Design Strategy for Future Antibiotics, PhD, Faculty of Science, Charles University

Czech Republic (the)

Visit course webpage

Photos and Videos

Study options for this course

The award	How you will study	Study duration	Course start	Domestic course fees	International course fees
PhD	Full-time	find out	find out	0	0

About Amphiphilic Peptidomimetics Containing Metallacarboranes as a Design Strategy for Future Antibiotics, PhD - at Faculty of Science, Charles University

Project Summary:

Amphiphilic peptidomimetics represent an attractive alternative to conventional antibiotics, because their selectivity and mechanism of action are based on different molecular principles. In this project, our main goal is to obtain a library of metallacarborane-containing peptidomimetics with potent antibacterial activity, high selectivity, and immunity to resistance development by bacteria. Two types of peptidomimetics will be obtained: peptoids and polymers. The amphiphilic character of peptidomimetics will be reinforced by the incorporation of hydrophilic cationic moieties and lipophilic metallacarboranes. To fully understand the antibacterial potential of these peptidomimetics, we are planning concerted physicochemical studies completed by a biological evaluation of antibacterial and antibiofilm activity, toxicity, and immunomodulatory activity. These studies will allow us to identify peptidomimetics with the best antibacterial activity and to understand the underlying molecular and supramolecular principles.

Related publications:

[1] Fink, K.; Uchman, M. Boron cluster compounds as new chemical leads for antimicrobial therapy. Coordination Chemistry Reviews 2021, 431(15), 213684. https://doi.org/10.1016/j.ccr.2020.213684.
[2] Vrbata, D.; Uchman M. Preparation of Lactic Acid- and Glucose-Responsive Poly(?-caprolactone)-b-Poly(ethylene oxide) Block Copolymer Micelles Using Phenylboronic Ester as a Sensitive Block Linkage. Nanoscale 2018, 10(18), 8428-8442. https://doi.org/10.1039/C7NR09427B.

The ideal candidate should have MSc. or equivalent in Chemistry, Physics, Material Science or a related field, working knowledge of English and basic knowledge of polymer

Learn more about Amphiphilic Peptidomimetics Containing Metallacarboranes as a Design Strategy for Future Antibiotics, PhD - at Faculty of Science, Charles University

Visit course webpage

Entry requirements

Contact Faculty of Science, Charles University to find course entry requirements.

Fees, Funding and Scholarships at Faculty of Science, Charles University

This text facilitates quick navigation of the various types of scholarships but does not provide a full list of rules and policies regulating this field. The granting and payments of scholarships is governed primarily by the Scholarships and Bursaries Rules of Charles University (cuni.cz/UKEN-727.html), the Rules for Granting Scholarships at FSc, and the relevant measures issued by the Dean (natur.cuni.cz/fakulta/studium/bc-nmgr/predpisy-a-poplatky/stipendia; Czech only).

Students may obtain the following scholarships:

accommodation bursary;
bursary for a student in difficult social circumstances;
scholarship for outstanding academic achievement (“mark-based”);
bursary in a case worthy of special consideration;
bursary to support study abroad;
bursary for a CU student in an acutely difficult situation;
bursary to support study in the Czech Republic;
bursary for excellent research, development, innovation, artistic, or other creative achievements contributing to enhanced knowledge;
scholarship for RDI (research, development, and innovation) under special legislation;
motivation bursary for 1st year bachelor’s programme students;
motivation bursary for 1st year post-bachelor’s programme students;
sports bursary;
doctoral bursary.

Certain scholarships are granted to students automatically (without student applications), whereas others are granted further to an application (electronic or paper, depending on the type of scholarship). Bursaries are neither taxed nor included in stated income. You can find answers to frequently asked questions regarding scholarships on the Faculty website (natur.cuni.cz/fakulta/studium/helpdesk/faq-stipendia; Czech only).

For more information check our dedicated website.